Possible superoxide radical-induced alteration of vascular reactivity in aortas from streptozotocin-treated rats.

@article{Chang1993PossibleSR,
  title={Possible superoxide radical-induced alteration of vascular reactivity in aortas from streptozotocin-treated rats.},
  author={K. C. Chang and Soo Youn Chung and Won Seog Chong and Jin Su Suh and Sun Hwa Kim and Hyung Kil Noh and B W Seong and Hyung Jong Ko and Kang Wook Chun},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={1993},
  volume={266 2},
  pages={992-1000}
}
We investigated the possible involvement of the superoxide (.O2-) radical in alterations of vascular reactivity and phosphoinositide (PI) turnover in aortas from streptozotocin (STZ)-induced diabetic (4 week) rats. STZ treatment increased the maximal contractile response of the aorta to norepinephrine (NE), phenylephrine (PE) and high K+, whereas the… CONTINUE READING