Possible stage-specific function of NF-kappaB during pre-B cell differentiation.


Lipopolysaccharide (LPS)-induced differentiation of the murine pre-B cell line 70Z/3 is a model for pre-B to B cell differentiation and has been used to show that the transcription factor NF-kappaB is essential to induce the expression of the Ig kappa gene. We have investigated the mechanism involved in late stages of the process when all cells have reached… (More)


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