Possible roles of thrombin-induced activation of protease-activated receptor 1 in human luteinized granulosa cells.

@article{Hirota2003PossibleRO,
  title={Possible roles of thrombin-induced activation of protease-activated receptor 1 in human luteinized granulosa cells.},
  author={Yasushi Hirota and Yutaka Osuga and Osamu Yoshino and Kaori Koga and Tetsu Yano and Tetsuya Hirata and Emi Nose and Takuya Ayabe and Akira Namba and Osamu Tsutsumi and Yuji Taketani},
  journal={The Journal of clinical endocrinology and metabolism},
  year={2003},
  volume={88 8},
  pages={3952-7}
}
The presence of thrombin and its receptor, protease-activated receptor 1 (PAR 1), in the ovary suggests that thrombin may regulate ovarian function. In particular, to address the possible role of thrombin in ovulation, a phenomenon displaying mimicry of inflammation, we investigated the effects of thrombin and PAR 1 on the production of inflammation-related substances in human luteinized granulosa cells (LGC). Thrombin stimulated the production of IL-8 and monocyte chemoattractant protein-1 by… CONTINUE READING

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