Possible roles for ATP release from RBCs exclude the cAMP-mediated Panx1 pathway.

@article{Keller2017PossibleRF,
  title={Possible roles for ATP release from RBCs exclude the cAMP-mediated Panx1 pathway.},
  author={Alexander S. Keller and Lukas D. Diederich and Christina Panknin and Leon J. DeLalio and Joshua C Drake and Robyn Sherman and Edwin K Jackson and Zhen Yan and Malte Kelm and Miriam M Cortese-Krott and Brant E Isakson},
  journal={American journal of physiology. Cell physiology},
  year={2017},
  volume={313 6},
  pages={C593-C603}
}
Red blood cell (RBC)-derived adenosine triphosphate (ATP) has been proposed as an integral component in the regulation of oxygen supply to skeletal muscle. In ex vivo settings RBCs have been shown to release ATP in response to a number of stimuli, including stimulation of adrenergic receptors. Further evidence suggested that ATP release from RBCs was dependent on activation of adenylate cyclase (AC)/cyclic adenosine monophosphate (cAMP)-dependent pathways and involved the pannexin 1 (Panx1… CONTINUE READING
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