Possible role of the first intron of c-H-ras in gene expression: anti-cancer elements in oncogenes.

Abstract

When members of ras gene family, which encode structurally related proteins of approximately 21,000 daltons (p21), are activated by either structural mutations or enhanced promoter activities, immortalized mammalian cells can be transformed into malignant forms. The ras genes are classified as "housekeeping genes" which express relatively constantly at low… (More)

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