Possible role of the JAK/STAT pathways in the regulation of T cell-interferon related genes in systemic lupus erythematosus.

@article{Kawasaki2011PossibleRO,
  title={Possible role of the JAK/STAT pathways in the regulation of T cell-interferon related genes in systemic lupus erythematosus.},
  author={Mikiko Kawasaki and Maki Fujishiro and Ayako Yamaguchi and Kazuhisa Nozawa and Hiroshi Kaneko and Yoshinari Takasaki and Kennji Takamori and Hideoki Ogawa and Iwao Sekigawa},
  journal={Lupus},
  year={2011},
  volume={20 12},
  pages={1231-9}
}
Changes in gene expression in CD3+ T cells associated with disease progression in systemic lupus erythematosus (SLE) patients were determined. The genes related to SLE disease-related activities were identified and their gene regulatory networks were investigated. Analyses of gene expression were performed by both DNA microarray and real-time quantitative reverse transcription polymerase chain reaction (qRT-PCR). The expression of certain genes including interferon (IFN) regulatory factor (IRF… CONTINUE READING

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