Possible role of telomerase activation in the multistep tumor progression of periampullary lesions in patients with familial adenomatous polyposis

@article{Mizumoto2001PossibleRO,
  title={Possible role of telomerase activation in the multistep tumor progression of periampullary lesions in patients with familial adenomatous polyposis},
  author={Kazuhiro Mizumoto and Yoshiaki Ogawa and Hideaki Niiyama and Eishi Nagai and Norihiro Sato and Taro Urashima and Takayuki Matsumoto and Mitsuo Iida and Masao Tanaka},
  journal={American Journal of Gastroenterology},
  year={2001},
  volume={96},
  pages={1261-1265}
}
OBJECTIVES:The role of telomerase in periampullary tumor progression in patients with familial adenomatous polyposis (FAP) was investigated.METHODS:Relative telomerase activity was measured using a telomerease amplification protocol in periampullary biopsy specimens of normal mucosa and adenoma obtained from patients with FAP, and was compared with that of periampullary normal mucosa and cancer specimens from patients without FAP.RESULTS:None of normal mucosa from the non-FAP patients showed a… CONTINUE READING