Possible role of stem cell factor as a serum factor: monoclonal anti-c-kit antibody abrogates interleukin-6-dependent colony growth in serum-containing culture.

@article{Shiohara1993PossibleRO,
  title={Possible role of stem cell factor as a serum factor: monoclonal anti-c-kit antibody abrogates interleukin-6-dependent colony growth in serum-containing culture.},
  author={Masaaki Shiohara and Kenichi Koike and Takekazu Kubo and Yusuke Amano and Minoru Takagi and Kenji Muraoka and Junji Nakao and Tatsutoshi Nakahata and Atsushi Komiyama},
  journal={Experimental hematology},
  year={1993},
  volume={21 7},
  pages={907-12}
}
The monoclonal rat anti-c-kit antibody (ACK2), which abrogates colony growth supported by stem cell factor (SCF), significantly inhibited the interleukin-6 (IL-6)-dependent growth of hematopoietic progenitors derived from spleen cells of normal and 5-fluorouracil (5-FU)-treated mice and from bone marrow cells of normal mice in serum-containing culture. The numbers and types of colonies supported by IL-3, granulocyte-macrophage colony-stimulating factor (GM-CSF) and granulocyte colony… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-8 of 8 extracted citations

Similar Papers

Loading similar papers…