Possible role of salsolinol quinone methide in the decrease of RCSN-3 cell survival.

@article{MartinezAlvarado2001PossibleRO,
  title={Possible role of salsolinol quinone methide in the decrease of RCSN-3 cell survival.},
  author={Pedro Martinez-Alvarado and A Dagnino-Subiabre and Irmgard B. Paris and Diana Metodiewa and Christopher J Welch and Claudio A Olea-Azar and Pablo Caviedes and Ra{\'u}l Caviedes and Juan Segura-Aguilar},
  journal={Biochemical and biophysical research communications},
  year={2001},
  volume={283 5},
  pages={1069-76}
}
The endogenous dopamine-derived neurotoxin salsolinol was found to decrease survival in the dopaminergic neuronal cell line RCSN-3, derived from adult rat substantia nigra in a concentration-dependent manner (208 microM salsolinol induced a 50% survival decrease). Incubation of RCSN-3 cells with 100 micro;M dicoumarol and salsolinol significantly decreased cell survival by 2.5-fold (P < 0.001), contrasting with a negligible effect on RCHT cells, which exhibited nearly a 5-fold lower nomifensine… CONTINUE READING