Possible role of procathepsin D in human cancer
@article{Vashishta2008PossibleRO, title={Possible role of procathepsin D in human cancer}, author={A. Vashishta and M. Fusek and V. Vetvicka}, journal={Folia Microbiologica}, year={2008}, volume={50}, pages={71-76} }
For the past ten years, our research has been focused on elucidating the mechanism by which procathepsin D (pCD) impacts cancer development. Various studies have shown that pCD is overexpressed and secreted by numerous cancer cell lines. After secretion, it exhibits “growth hormone-like” activity on cancerous cells but the exact mechanism of this mitogenic activity is not yet understood. The activation peptide of pCD (APpCD) (which is cleaved off upon activation of the zymogen) is responsible… CONTINUE READING
4 Citations
Effect of procathepsin D activation peptide on gene expression of breast cancer cells.
- Biology, Medicine
- Cancer letters
- 2006
- 17
- PDF
Cathepsin D--many functions of one aspartic protease.
- Biology, Medicine
- Critical reviews in oncology/hematology
- 2008
- 450
References
SHOWING 1-10 OF 61 REFERENCES
Procathepsin D in breast cancer: What do we know? Effects of ribozymes and other inhibitors
- Biology, Medicine
- Cancer Gene Therapy
- 2002
- 41
- PDF
Mitogenic function of human procathepsin D: the role of the propeptide.
- Biology, Medicine
- The Biochemical journal
- 1994
- 108
Effect of procathepsin D and its activation peptide on prostate cancer cells.
- Biology, Medicine
- Cancer letters
- 1998
- 36
Anti‐human procathepsin D activation peptide antibodies inhibit breast cancer development
- Biology, Medicine
- Breast Cancer Research and Treatment
- 2004
- 49
Analysis of the interaction of procathepsin D activation peptide with breast cancer cells
- Biology, Medicine
- International journal of cancer
- 1997
- 56
Modulation of proliferation and chemosensitivity by procathepsin D and its peptides in ovarian cancer.
- Biology, Medicine
- Gynecologic oncology
- 1999
- 28
Cathepsin D in the malignant progression of neoplastic diseases (review).
- Biology, Medicine
- Anticancer research
- 1992
- 104
Cathepsin D expression levels in nongynecological solid tumors: Clinical and therapeutic implications
- Medicine, Biology
- Clinical & Experimental Metastasis
- 2004
- 77
- PDF
Biological and clinical significance of cathepsin D in breast cancer.
- Chemistry, Medicine
- Acta oncologica
- 1992
- 109
Human procathepsin D: three-dimensional model and isolation.
- Chemistry, Medicine
- Advances in experimental medicine and biology
- 1995
- 13