Possible role of procathepsin D in human cancer

  title={Possible role of procathepsin D in human cancer},
  author={A. Vashishta and M. Fusek and V. Vetvicka},
  journal={Folia Microbiologica},
  • A. Vashishta, M. Fusek, V. Vetvicka
  • Published 2008
  • Biology, Medicine
  • Folia Microbiologica
  • For the past ten years, our research has been focused on elucidating the mechanism by which procathepsin D (pCD) impacts cancer development. Various studies have shown that pCD is overexpressed and secreted by numerous cancer cell lines. After secretion, it exhibits “growth hormone-like” activity on cancerous cells but the exact mechanism of this mitogenic activity is not yet understood. The activation peptide of pCD (APpCD) (which is cleaved off upon activation of the zymogen) is responsible… CONTINUE READING
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