Possible role of insertion sequence IS257 in dissemination and expression of high- and low-level trimethoprim resistance in staphylococci.

@article{Leelaporn1994PossibleRO,
  title={Possible role of insertion sequence IS257 in dissemination and expression of high- and low-level trimethoprim resistance in staphylococci.},
  author={Amornrut Leelaporn and Neville Firth and Mairi Byrne and Eric Roper and RonaldA. Skurray},
  journal={Antimicrobial agents and chemotherapy},
  year={1994},
  volume={38 10},
  pages={
          2238-44
        }
}
The transposon-like structure Tn4003 and related elements were found to encode high- and low-level trimethoprim resistance (Tpr) in Staphylococcus aureus and coagulase-negative staphylococci. By using transcriptional fusions in Escherichia coli, the variation in resistance levels was found to correlate with the transcriptional activity of the region presumed to carry the promoter for the operon containing the Tpr dihydrofolate reductase gene, dfrA, encoded by these elements. The reduced… CONTINUE READING
BETA

Similar Papers

Citations

Publications citing this paper.
SHOWING 1-10 OF 15 CITATIONS