Possible role of increased oxidative stress in pulmonary hypertension in experimental diaphragmatic hernia

@article{ArasLpez2015PossibleRO,
  title={Possible role of increased oxidative stress in pulmonary hypertension in experimental diaphragmatic hernia},
  author={Rosa Aras-L{\'o}pez and Juan Antonio Tovar and L. Bengoechea Mart{\'i}nez},
  journal={Pediatric Surgery International},
  year={2015},
  volume={32},
  pages={141-145}
}
Congenital diaphragmatic hernia (CDH) is one of the causes of respiratory failure in newborns due to lung hypoplasia and pulmonary abnormalities leading to pulmonary hypertension (PH). NAD(P)H oxidase (Nox) is a family of isoenzymes that generate reactive oxygen species (ROS) which can contribute to PH-induced vascular dysfunction. On the other hand, superoxide dismutase (SOD) 1–2 and catalase are the antioxidant enzymes that eliminate the excess of ROS in pulmonary vascular cells. Our aim is… CONTINUE READING
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