Possible role of hyaluronate in experimental renal stone formation in rabbits.

@article{Wakatsuki1985PossibleRO,
  title={Possible role of hyaluronate in experimental renal stone formation in rabbits.},
  author={Akira Wakatsuki and Shin Nishio and Hiroaki Iwata and Kentaro Ochi and M. D. Muneyuki Takeuchi and Akihiko Matsumoto},
  journal={The Journal of urology},
  year={1985},
  volume={133 2},
  pages={319-23}
}
We produced renal stones in rabbits by modifying Itatani's method, ligation of the right ureter followed by ureteroneocystostomy 1 week later. Renal stones formed in all animals within 2 weeks after ureteroneocystostomy. We measured the components of glycosaminoglycan in the stone matrix, renal tissue and urine by 2-dimensional electrophoresis. Glycosaminoglycan of the stone matrix consisted solely of hyaluronate. Glycosaminoglycan of the control normal urine consisted of only chondroitin… CONTINUE READING