Possible role of dimerization in human immunodeficiency virus type 1 genome RNA packaging.

@article{Sakuragi2003PossibleRO,
  title={Possible role of dimerization in human immunodeficiency virus type 1 genome RNA packaging.},
  author={Jun-ichi Sakuragi and Shigeharu Ueda and Aikichi Iwamoto and Tatsuo Shioda},
  journal={Journal of virology},
  year={2003},
  volume={77 7},
  pages={4060-9}
}
The dimer initiation site/dimer linkage sequence (DIS/DLS) region in the human immunodeficiency virus type 1 (HIV-1) RNA genome is suggested to play important roles in various steps of the virus life cycle. However, due to the presence of a putative DIS/DLS region located within the encapsidation signal region (E/psi), it is difficult to perform a mutational analysis of DIS/DLS without affecting the packaging of RNA into virions. Recently, we demonstrated that duplication of the DIS/DLS region… CONTINUE READING

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