Possible role of central alpha 1-adrenoceptors in the control of the autonomic nervous system in normotensive and spontaneously hypertensive rats.

@article{Huchet1982PossibleRO,
  title={Possible role of central alpha 1-adrenoceptors in the control of the autonomic nervous system in normotensive and spontaneously hypertensive rats.},
  author={A M Huchet and M F Doursout and Jamel Chelly and H{\'e}l{\`e}ne Schmitt},
  journal={European journal of pharmacology},
  year={1982},
  volume={85 2},
  pages={239-42}
}
The cardiovascular effects of AR-C 239, a new and selective alpha 1-adrenoceptor blocking drug were studied in normotensive and spontaneously hypertensive rats (SHR). AR-C 239 (300 micrograms/kg i.v.) did not change the heart rate in control (without pretreatment) and bilaterally vagotomized normotensive rats, but induced significant bradycardia in rats… CONTINUE READING