Possible role of calcium release from the sarcoplasmic reticulum in pacemaking in guinea-pig sino-atrial node.

@article{Rigg1996PossibleRO,
  title={Possible role of calcium release from the sarcoplasmic reticulum in pacemaking in guinea-pig sino-atrial node.},
  author={Lauren Rigg and Derek A. Terrar},
  journal={Experimental physiology},
  year={1996},
  volume={81 5},
  pages={877-80}
}
Ryanodine and cyclopiazonic acid were used to alter the ability of the sarcoplasmic reticulum (SR) to store calcium. Interventions of this kind significantly reduced the rate of spontaneous beating of guinea-pig sino-atrial node preparations. In addition, both of these drugs decreased the rate of rise and modified other characteristics of the action… CONTINUE READING