Possible role of adaptive mutation in resistance to antiandrogen in prostate cancer cells.

@article{Hara2005PossibleRO,
  title={Possible role of adaptive mutation in resistance to antiandrogen in prostate cancer cells.},
  author={Takahito Hara and Jin Kouno and Kazuyo Nakamura and Masami Kusaka and Masuo Yamaoka},
  journal={The Prostate},
  year={2005},
  volume={65 3},
  pages={
          268-75
        }
}
  • Takahito Hara, Jin Kouno, +2 authors Masuo Yamaoka
  • Published in The Prostate 2005
  • Biology, Medicine
  • BACKGROUND Some mutations of androgen receptor (AR) confer resistance to antiandrogen to prostate cancer (PC) cells. Previously we reported that LNCaP-cxD2 cells established from androgen-dependent LNCaP-FGC PC cells as an antiandrogen bicalutamide-resistant subline harbor W741C/L mutation in the AR gene. In this report, we examined one possible mechanism of the resistance. METHODS Change in the gene expression and the protein levels relevant to mutagenesis in LNCaP-FGC cells during… CONTINUE READING

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