Possible role of VEGF in the progression of kidney disease in streptozotocin (STZ)-induced diabetic rats: effects of an ACE inhibitor and an angiotensin II receptor antagonist.

Abstract

Two endothelium-derived factors, endothelin (ET), a vasoconstrictor, and vascular endothelial growth factor (VEGF), an angiogenic factor are thought to be involved in the pathogenesis of diabetic vascular complications. The aim of this study was to determine the effects of an angiotensin II type I (AT-1) receptor antagonist and an ACE inhibitor on the… (More)

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Cite this paper

@article{Kakizawa2004PossibleRO, title={Possible role of VEGF in the progression of kidney disease in streptozotocin (STZ)-induced diabetic rats: effects of an ACE inhibitor and an angiotensin II receptor antagonist.}, author={Hideyuki Kakizawa and Yoshito Itoh and Sadao Imamura and Tadashi Matsumoto and Yoko Ishiwata and Yoshikiyo Ono and Kei Yamamoto and Tomohiro Kato and Naokazu Hayakawa and Naohisa Oda and Yuko Goto and Akio Nagasaka and Takao Senda and Mitsuyasu Itoh}, journal={Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme}, year={2004}, volume={36 7}, pages={458-64} }