Possible role of PGRMC1 in breast cancer development

@article{Neubauer2013PossibleRO,
  title={Possible role of PGRMC1 in breast cancer development},
  author={H. Neubauer and Q. Ma and J. Zhou and Q. Yu and X. Ruan and H. Seeger and T. Fehm and A. Mueck},
  journal={Climacteric},
  year={2013},
  volume={16},
  pages={509 - 513}
}
  • H. Neubauer, Q. Ma, +5 authors A. Mueck
  • Published 2013
  • Medicine
  • Climacteric
  • Abstract Hormone therapy may increase the risk of breast cancer. Thus, especially the addition of synthetic progestins may play a decisive role according to the results of clinical studies. Overexpression of a special receptor, i.e. the progesterone receptor membrane component-1 (PGRMC1), may offer a potential new pathway to explain the observed increase in breast cancer risk in the combined arm of the Women's Health Initiative. PGRMC1 is expressed in breast cancer tissue and may be important… CONTINUE READING
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