Possible role of Ca2+ in heavy metal cytotoxicity.

@article{Viarengo1991PossibleRO,
  title={Possible role of Ca2+ in heavy metal cytotoxicity.},
  author={Aldo Viarengo and Pierluigi Nicotera},
  journal={Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology},
  year={1991},
  volume={100 1-2},
  pages={81-4}
}
1. Organic xenobiotic metabolism often results in oxidative stress, involving GSH depletion, alteration of thiol/disulphide balance and peroxidation of membrane lipids. These events can lead to the disruption of Ca2+ homeostasis, through impairment of the Ca2+ translocases present in cellular membranes. Inhibition of the activity of Ca,Mg-ATPases due to oxidation of their SH groups would lead to uncontrolled rises in cytosolic Ca2+ levels resulting in loss of cell viability. 2. These… CONTINUE READING

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