Possible role of CD5+ B cells expressing CD23 in mediating the elevation of serum-soluble CD23 in patients with rheumatoid arthritis.

Since increased levels of serum soluble CD23/Fc epsilon RII (sCD23) were evidently demonstrated in patients with autoimmune diseases such as rheumatoid arthritis (RA), the possible mechanisms responsible for the elevation of serum sCD23 were investigated in RA patients. In keeping with increased serum sCD23, high proportion of CD23+ B cells was detected in… (More)