Possible protective role of the 489C>T P2X7R polymorphism in Alzheimer's disease

Abstract

Inflammation is a key factor in the onset and progression of Alzheimer's disease (AD). The P2X7 receptor (P2X7R) is increasingly recognized as key pro-inflammatory receptor. A recent study has shown that activation of microglia by amyloid β (Aβ) and associated release of IL-1β, requires P2X7R expression. In this study we assessed by RT-PCR in genomic DNA… (More)
DOI: 10.1016/j.exger.2014.10.009

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