Possible nitric oxide mechanism involved in the protective effect of L-theanine on haloperidol-induced orofacial dyskinesia

@article{Tsai2019PossibleNO,
  title={Possible nitric oxide mechanism involved in the protective effect of L-theanine on haloperidol-induced orofacial dyskinesia},
  author={Cheng-Chia Tsai and Mao-Hsien Wang and Kuo Chi Chang and Hung-Sheng Soung and Chih-Chuan Yang and Hsiang-Chien Tseng},
  journal={Chinese Journal of Physiology},
  year={2019},
  volume={62},
  pages={17 - 26}
}
Having powerful antioxidative properties, L-theanine (LT), one of the major amino acid components in green tea, has potent anti-oxidative and neuroprotective effects. In this study, we examined the potential protective effects of LT on haloperidol (HAL)-induced orofacial dyskinesia (OD) in rats. HAL treatment (1 mg/kg intraperitoneally for 21 days) induced OD; significant increases (P < 0.001) in the frequency of vacuous chewing movement and tongue protrusion as well as the duration of facial… 
3 Citations
Naringin Ameliorates Haloperidol-Induced Neurotoxicity and Orofacial Dyskinesia in a Rat Model of Human Tardive Dyskinesia.
TLDR
The neuroprotective effects of NAR are demonstrated against HAL-induced OD, suggesting that NAR may help in delaying or treating human tardive dyskinesia in clinical settings.
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LT treatment significantly and dose-dependently alleviated CCI-induced nociceptive pain thresholds and ameliorated abnormal nerve conduction and functional loss in rats with CCI, thus making it potentially useful as an adjuvant to conventional treatment.
Haloperidol elicits oxidative damage in the brain of rats submitted to the ketamine-induced model of schizophrenia
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A possible energy dysfunction or a haloperidol effect targeting the glutathione enzymes, and then disrupting the redox homeostasis in neurons, could not be ruled out, although further studies are required to confirm or refute a direct interaction.

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