Possible nitric oxide mechanism involved in the protective effect of L-theanine on haloperidol-induced orofacial dyskinesia

  title={Possible nitric oxide mechanism involved in the protective effect of L-theanine on haloperidol-induced orofacial dyskinesia},
  author={Cheng-Chia Tsai and Mao-Hsien Wang and Kuo Chi Chang and Hung-Sheng Soung and Chih-Chuan Yang and Hsiang-Chien Tseng},
  journal={Chinese Journal of Physiology},
  pages={17 - 26}
Having powerful antioxidative properties, L-theanine (LT), one of the major amino acid components in green tea, has potent anti-oxidative and neuroprotective effects. In this study, we examined the potential protective effects of LT on haloperidol (HAL)-induced orofacial dyskinesia (OD) in rats. HAL treatment (1 mg/kg intraperitoneally for 21 days) induced OD; significant increases (P < 0.001) in the frequency of vacuous chewing movement and tongue protrusion as well as the duration of facial… 
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A protective effect of Morus alba extract against haloperidol-induced orofacial dyskinesia and oxidative stress is suggested.
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The neuroprotective potential of L-theanine involves inhibition of detrimental nitric oxide production and prevention of neurotransmitters alteration in the striatum and its possible mechanism is explored.
Neuroprotective effects of theanine and its preventive effects on cognitive dysfunction.
  • T. Kakuda
  • Biology, Medicine
    Pharmacological research
  • 2011
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Protective effect of L-Theanine against aluminium induced neurotoxicity in cerebral cortex, hippocampus and cerebellum of rat brain – histopathological, and biochemical approach
The present study clearly indicates the potential of L-Theanine in counteracting the damage inflicted by aluminium on rat brain regions and indicates the role of antioxidant system in alleviating such negative effects.
Haloperidol cytotoxicity and its relation to oxidative stress.
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