Possible mechanisms underlying development of transfusion-related acute lung injury: roles of anti-major histocompatibility complex class II DR antibody.

@article{Nishimura2003PossibleMU,
  title={Possible mechanisms underlying development of transfusion-related acute lung injury: roles of anti-major histocompatibility complex class II DR antibody.},
  author={Motoko Nishimura and Shigeki Mitsunaga and Yoshihide Ishikawa and Masahiro Satake},
  journal={Transfusion medicine},
  year={2003},
  volume={13 3},
  pages={141-7}
}
Anti-major histocompatibility complex (anti-MHC) antibodies (Abs) and antipolymorphonuclear neutrophil (anti-PMN) Abs are generally considered as the main causes of the development of transfusion-related acute lung injury (TRALI), which is one of the most severe and sometimes lethal side effects of transfusion. These Abs are postulated to activate recipient… CONTINUE READING