Possible mechanisms of vasorelaxation for 5,7‐dimethoxyflavone from Kaempferia parviflora in the rat aorta

@article{Tepareenan2010PossibleMO,
  title={Possible mechanisms of vasorelaxation for 5,7‐dimethoxyflavone from Kaempferia parviflora in the rat aorta},
  author={Patcharin Tep-areenan and Pattara Sawasdee and Michael D Randall},
  journal={Phytotherapy Research},
  year={2010},
  volume={24}
}
The present study investigated the vascular effects of 5,7‐dimethoxyflavone (DMF), isolated from the rhizomes of Kaempferia parviflora (KP), on rat isolated aortic rings and its possible mechanisms. DMF (1–100 μm) caused concentration‐dependent relaxations in aortic rings precontracted with methoxamine. This effect was significantly reduced by removal of the endothelium, and after pretreatment with NG‐nitro‐L‐arginine methyl ester (L‐NAME, 300 μm), indomethacin (10 μm) and 1H‐[1,2,4]oxadiazolo… 
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