Possible mechanism of painful radiculopathy in lumbar disc herniation.

  title={Possible mechanism of painful radiculopathy in lumbar disc herniation.},
  author={Mamoru Kawakami and Tetsuya Tamaki and Nobuhiro Hayashi and Hiroshi Hashizume and Hideto Nishi},
  journal={Clinical orthopaedics and related research},
The pathophysiologic mechanisms of painful radiculopathy caused by a herniated intervertebral disc remain unknown. This study sought to determine whether the autologous intervertebral disc produces pain related behavior and whether phospholipase A2 and nitric oxide are involved in the pathophysiologic mechanism producing the behavior. A rat model, in which autologous intervertebral discs were implanted on the nerve root in the lumbar spine, was used to measure hyperalgesia, which is a pain… CONTINUE READING