Possible mechanism of immunosuppressive effect of scoparone (6,7-dimethoxycoumarin).

@article{Huang1992PossibleMO,
  title={Possible mechanism of immunosuppressive effect of scoparone (6,7-dimethoxycoumarin).},
  author={H C Huang and Yuan Li Huang and Jay Han-Chieh Chang and C. C. Chen and Yan Tony Lee},
  journal={European journal of pharmacology},
  year={1992},
  volume={217 2-3},
  pages={143-8}
}
The possible mechanism of the immunosuppressive effect of scoparone (6,7-dimethoxycoumarin) was investigated. Human peripheral blood mononuclear cells (10(6) cells/ml) were stimulated with 0.25% phytohemagglutinin (PHA) and the proliferative response was determined from the uptake of tritiated thymidine. Scoparone (10(-6) to 3 x 10(-4) M) reduced the… CONTINUE READING