Possible mechanism for mianserin induced neutropenia associated with saturable elimination kinetics.

Abstract

Two cases of mianserin induced neutropenia associated with prolonged elimination of the drug were studied. In each case the pharmacokinetic profile suggested saturable elimination kinetics, and the temporal relation of mianserin concentrations and the neutrophil count suggested a direct toxic effect of mianserin on the bone marrow. Until further studies are carried out the plasma mianserin concentration and neutrophil count should be measured in any patient who develops an infection while taking this drug.

Cite this paper

@article{ODonnell1985PossibleMF, title={Possible mechanism for mianserin induced neutropenia associated with saturable elimination kinetics.}, author={John L O'Donnell and John Sharman and Evan James Begg and Barry M. Colls and Peter W Moller}, journal={British medical journal}, year={1985}, volume={291 6506}, pages={1375-6} }