Possible mechanism(s) for relaxant effect of aqueous and macerated extracts from Nigella sativa on tracheal chains of guinea pig

@article{Boskabady2004PossibleMF,
  title={Possible mechanism(s) for relaxant effect of aqueous and macerated extracts from Nigella sativa on tracheal chains of guinea pig},
  author={Mohammad Hossein Boskabady and Batool Shirmohammadi and Parastoo Jandaghi and Sahar Kiani},
  journal={BMC Pharmacology},
  year={2004},
  volume={4},
  pages={3 - 3}
}
BACKGROUND In previous studies, the relaxant, anticholinergic (functional antagonism) and antihistaminic effects of Nigella sativa have been demonstrated on guinea pig tracheal chains. To elucidate the other mechanisms responsible for the relaxant effect of this plant, its inhibitory effect on the calcium channel was examined in this study. RESULTS The inhibitory effects of both concentrations of diltiazem in all three groups of experiments were significantly greater than those of saline (p… CONTINUE READING