Possible levomepromazine–clozapine interaction: Two case reports

  title={Possible levomepromazine–clozapine interaction: Two case reports},
  author={Francesca Bugamelli and Roberto Mandrioli and Ernst Kenndler and Claudio Bartoletti and Maria Augusta Raggi},
  journal={Progress in Neuro-Psychopharmacology and Biological Psychiatry},
OBJECTIVE To report and comment upon two cases of suspected pharmacological interaction between the "classical" neuroleptic levomepromazine (LMP) and the "atypical" antipsychotic clozapine (CLZ). CASE SUMMARY The patients who simultaneously took the two drugs had unusually low plasma levels of CLZ and its metabolites, even though they took high doses of CLZ. The patients were considered "non-responders" to the treatment by the psychiatrist. When LMP was withdrawn from the therapy, plasma… CONTINUE READING

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