Possible involvement of toll-like receptor 4/myeloid differentiation factor-2 activity of opioid inactive isomers causes spinal proinflammation and related behavioral consequences.

@article{Hutchinson2010PossibleIO,
  title={Possible involvement of toll-like receptor 4/myeloid differentiation factor-2 activity of opioid inactive isomers causes spinal proinflammation and related behavioral consequences.},
  author={Mark R Hutchinson and Susannah S Lewis and Benjamen D Coats and Niloofar Rezvani and Y Zhang and Julie L Wieseler and Andrew Alexander Somogyi and Hang Yin and Steven F. Maier and Kenner C. Rice and Linda R. Watkins},
  journal={Neuroscience},
  year={2010},
  volume={167 3},
  pages={880-93}
}
Opioid-induced glial activation and its proinflammatory consequences have been associated with both reduced acute opioid analgesia and the enhanced development of tolerance, hyperalgesia and allodynia following chronic opioid administration. Intriguingly, recent evidence demonstrates that these effects can result independently from the activation of… CONTINUE READING