Corpus ID: 38664412

Possible involvement of the adenosinergic system in flunarizine anticonvulsant activity in rats.

@article{Popoli1990PossibleIO,
  title={Possible involvement of the adenosinergic system in flunarizine anticonvulsant activity in rats.},
  author={P. Popoli and A. P{\`e}zzola and A. Scotti de Carolis},
  journal={Archives internationales de pharmacodynamie et de therapie},
  year={1990},
  volume={306},
  pages={
          45-56
        }
}
  • P. Popoli, A. Pèzzola, A. Scotti de Carolis
  • Published 1990
  • Chemistry, Medicine
  • Archives internationales de pharmacodynamie et de therapie
  • The present work deals with an EEG and behavioral study on the effects of the calcium antagonist flunarizine against the convulsions due to pentylenetetrazole in rats. Flunarizine (1.5-18 mg/kg, i.p.) has a dose-dependent protective effect against pentylenetetrazole-induced seizures (50 mg/kg, i.p.). Tonic seizures were primarily affected by flunarizine. N6-L-phenylisopropyl-adenosine (an A1 adenosine receptor agonist) potentiated the anticonvulsant effects of flunarizine at the dose of 0.05 mg… CONTINUE READING