Possible involvement of the activation of voltage-sensitive calcium channels in the ameliorating effects of nefiracetam on scopolamine-induced impairment of performance in a passive avoidance task.

@article{Yamada1994PossibleIO,
  title={Possible involvement of the activation of voltage-sensitive calcium channels in the ameliorating effects of nefiracetam on scopolamine-induced impairment of performance in a passive avoidance task.},
  author={Kiyoyasu Yamada and Shinsuke Nakayama and Tadashi Shiotani and Takehiro Hasegawa and Toshitaka Nabeshima},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={1994},
  volume={270 3},
  pages={881-92}
}
We investigated the effects of various types of calcium channel antagonists on the amelioration by nefiracetam [N-(2,6-dimethylphenyl)-2-(2-oxo-1-pyrrolidinyl) acetamide, DM-9384] of scopolamine-induced impairment of performance in a passive avoidance task in mice. The reversal of the scopolamine-induced impairment of performance by nefiracetam showed a bell-shaped plot. Both i.p. and i.c.v. injection of L-type calcium channel antagonists such as nifedipine and flunarizine attenuated the… CONTINUE READING