Possible involvement of stem cell factor and endothelin-1 in the emergence of pigmented squamous cell carcinoma in oral mucosa.

@article{Satomura2007PossibleIO,
  title={Possible involvement of stem cell factor and endothelin-1 in the emergence of pigmented squamous cell carcinoma in oral mucosa.},
  author={Kazuhito Satomura and Reiko Tokuyama and Yasuhumi Yamasaki and Tetsuya Yuasa and Seiko Tatehara and Naozumi Ishimaru and Yoshio Hayashi and Masaru Nagayama},
  journal={Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology},
  year={2007},
  volume={36 10},
  pages={621-4}
}
We present here the clinical, morphological and immunohistochemical features of a pigmented squamous cell carcinoma (SCC) in the oral mucosa of the hard palate of a 76-year-old Japanese man. He underwent a partial resection of the maxilla subsequent to radiotherapy. The tumor was typical, moderately well-differentiated SCC but had many melanocytes (melanocytosis) within it. Immunohistochemical analysis for stem cell factor (SCF) and endothelin-1, both of which are known to stimulate… CONTINUE READING

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