Possible involvement of prolactin in endocrine-resistant metastatic prostate cancer.

  title={Possible involvement of prolactin in endocrine-resistant metastatic prostate cancer.},
  author={Paolo Lissoni and A. Bignami and Luciano Frontini and Vittorio Manganini and Elisa Dapretto and Gianstefano Gardani and Paola Vigan{\'o} and Guido Strada},
  journal={The International journal of biological markers},
  volume={20 2},
The hormone resistance of prostate cancer has been proved to depend at least in part on enhanced neuroendocrine activity and the resultant increase in blood concentrations of chromogranin A. Other experimental observations have suggested the involvement of prolactin (PRL), which appears to be a potential growth factor for prostate cancer. Abnormally high levels of PRL have been detected in metastatic prostate cancer, but the clinical significance of this finding has still to be clarified. In an… CONTINUE READING

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