Possible involvement of opioidergic and serotonergic mechanisms in antinociceptive effect of paroxetine in acute pain.

Abstract

Antidepressant drugs, especially tricyclics have been widely used in the treatment of chronic pain, but not in acute pain. Because of numerous undesirable side effects, the selective serotonin reuptake inhibitors (SSRIs), with their favorable side effect profile, are preferred nowadays. An activation of the endogenous opioid mechanisms or potentiation of… (More)

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Cite this paper

@article{Duman2004PossibleIO, title={Possible involvement of opioidergic and serotonergic mechanisms in antinociceptive effect of paroxetine in acute pain.}, author={Erdem Nail Duman and Murat Kesim and Mine Kadioglu and Ersin Yaris and Nuri Ihsan Kalyoncu and Nesrin Erciyes}, journal={Journal of pharmacological sciences}, year={2004}, volume={94 2}, pages={161-5} }