Possible involvement of neuropeptide Y in the seasonal control of hydroxyindole-O-methyltransferase activity in the pineal gland of the European hamster (Cricetus cricetus)

@article{Ribelayga1998PossibleIO,
  title={Possible involvement of neuropeptide Y in the seasonal control of hydroxyindole-O-methyltransferase activity in the pineal gland of the European hamster (Cricetus cricetus)},
  author={Christophe Ribelayga and Paul Pevet and Val{\'e}rie Simonneaux},
  journal={Brain Research},
  year={1998},
  volume={801},
  pages={137-142}
}
Hydroxyindole-O-methyltransferase (HIOMT) catalyses the last step of all the 5-methoxyindoles synthesized in the pineal gland. The synthetic activity of this neuroendocrine structure is driven not only by noradrenaline but also by various neuropeptides. Recently we have established (1) that one of these neuropeptides, neuropeptide Y (NPY), stimulates specifically HIOMT activity in rat pinealocytes and (2) that the density of the NPY-immunoreactive (NPY-IR) fibers innervating the pineal gland of… CONTINUE READING
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