Possible involvement of glial cell line-derived neurotrophic factor and its receptor, GFRalpha1, in survival and maturation of thymocytes.

@article{Kondo2003PossibleIO,
  title={Possible involvement of glial cell line-derived neurotrophic factor and its receptor, GFRalpha1, in survival and maturation of thymocytes.},
  author={Sachiko Kondo and Hiroyuki Kishi and Yoshiharu Tokimitsu and Atsushi Muraguchi},
  journal={European journal of immunology},
  year={2003},
  volume={33 8},
  pages={2233-40}
}
The glial cell line-derived neurotrophic factor (GDNF) and its receptors (GFR) play important roles in the promotion of survival and differentiation of central and peripheral neuronal populations. We show that GFRalpha1, a component of GDNF receptor, was expressed in thymocytes at an early stage of thymocyte-development and was involved in the survival of thymocyte precursors. GFRalpha1and GDNF were expressed in thymus, but not in spleen or lymph nodes in adult mice. During embryonic thymocyte… CONTINUE READING