Possible involvement of endothelium-derived hyperpolarizing factor (EDHF) in the depressor responses to platelet activating factor (PAF) in rats.

@article{Tanaka2000PossibleIO,
  title={Possible involvement of endothelium-derived hyperpolarizing factor (EDHF) in the depressor responses to platelet activating factor (PAF) in rats.},
  author={Yoshio Tanaka and Seiichi Hayakawa and Takumi Imai and Aya Akutsu and Hiroko Hirano and Hikaru Tanaka and T Nakahara and Kuniaki Ishii and Koki Shigenobu},
  journal={British journal of pharmacology},
  year={2000},
  volume={131 6},
  pages={
          1113-20
        }
}
  • Yoshio Tanaka, Seiichi Hayakawa, +6 authors Koki Shigenobu
  • Published in
    British journal of…
    2000
  • Chemistry, Medicine
  • 1. In anaesthetized rats, platelet activating factor (PAF; 1 microg kg(-1)) decreased mean arterial blood pressure by around 60 mmHg (n=18). This depressor response was completely blocked by the PAF antagonist, CV-6209 (1 mg kg(-1)), indicating the role of PAF-specific receptor in the response. 2. N(G)-nitro-L-arginine methyl ester (L-NAME; 50 mg kg(-1)), an NO synthase inhibitor, profoundly elevated systemic blood pressure (n=19), indicating an important role of NO in the basal blood pressure… CONTINUE READING

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