Possible involvement of endogenous 5-HT in aggravation of cerulein-induced acute pancreatitis in mice.

@article{Hamada2007PossibleIO,
  title={Possible involvement of endogenous 5-HT in aggravation of cerulein-induced acute pancreatitis in mice.},
  author={Kentaro Hamada and Masanori Yoshida and Hiroyuki Isayama and Yoshiki Yagi and Shuichi Kanazashi and Yasunari Kashihara and Koji Takeuchi and Isamu Yamaguchi},
  journal={Journal of pharmacological sciences},
  year={2007},
  volume={105 3},
  pages={240-50}
}
The aim of the present study was to elucidate the pathogenic role of endogenous 5-HT in pancreatitis. Injections of cerulein at hourly intervals caused edematous pancreatitis in mice characterized by hyperenzymemia and histological alterations. While the cerulein-induced hyperenzymemia was attenuated in mice pretreated with p-CPA, a 5-HT depletor, it was exaggerated by the preferential 5-HT2A agonist (DOI), but not by the preferential 5-HT2B agonist (BW723C86) or the preferential 5-HT2C agonist… CONTINUE READING