Possible involvement of complement factor C1q in the clearance of extracellular neuromelanin from the substantia nigra in Parkinson disease.

@article{Depboylu2011PossibleIO,
  title={Possible involvement of complement factor C1q in the clearance of extracellular neuromelanin from the substantia nigra in Parkinson disease.},
  author={Candan Depboylu and Martin K-H Schaefer and Oscar Arias-Carri{\'o}n and Wolfgang Hermann Oertel and Eberhard Weihe and G{\"u}nter U. H{\"o}glinger},
  journal={Journal of neuropathology and experimental neurology},
  year={2011},
  volume={70 2},
  pages={125-32}
}
Activation of the complement system promotes the removal of pathogens and tissue damage products from the brain and may also be involved in neuronal cell death in neurodegenerative diseases. Here, we analyzed the expression of C1q, the initial recognition subcomponent of the classic complement cascade, in the substantia nigra pars compacta (SNc) in… CONTINUE READING