Possible involvement of circulating fibroblast growth factor 23 in the development of secondary hyperparathyroidism associated with renal insufficiency.

@article{Shigematsu2004PossibleIO,
  title={Possible involvement of circulating fibroblast growth factor 23 in the development of secondary hyperparathyroidism associated with renal insufficiency.},
  author={Takashi Shigematsu and Junichiro James Kazama and Takeyoshi Yamashita and Seiji Fukumoto and Tatsuo Hosoya and Fumitake Gejyo and Masafumi Fukagawa},
  journal={American journal of kidney diseases : the official journal of the National Kidney Foundation},
  year={2004},
  volume={44 2},
  pages={
          250-6
        }
}
BACKGROUND Fibroblast growth factor 23 (FGF-23) is a recently identified polypeptide that promotes renal phosphate excretion and decreases serum 1,25-dihydroxyvitamin D3 (1,25D) levels. Serum FGF-23 levels are extraordinarily elevated in patients with end-stage renal failure. METHODS Blood and urine samples were obtained from 62 predialysis patients (age, 51.3 +/- 14.0 years; range, approximately 18 to 76 years; 32 men, 30 women). Serum FGF-23 levels were determined by means of a sandwich… CONTINUE READING
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