Possible involvement of caspase-7 in cell cycle progression at mitosis.

  title={Possible involvement of caspase-7 in cell cycle progression at mitosis.},
  author={Toshiaki Hashimoto and Lisa Yamauchi and Tony Hunter and Ushio Kikkawa and Shinji Kamada},
  journal={Genes to cells : devoted to molecular & cellular mechanisms},
  volume={13 6},
Caspases are suggested to play essential roles not only in apoptotic but also in non-apoptotic functions. However, the contribution of caspases to the cell cycle regulation is unclear. Here we found that caspases including caspase-3, caspase-7, caspase-8 and caspase-9 were activated during mitosis. Chemically synthesized caspase inhibitors delayed mitotic progression and induced accumulation of mitotic cells, which exhibited abnormal chromatin condensation and incomplete chromosome segregation… CONTINUE READING