Possible involvement of both mitochondria- and endoplasmic reticulum-dependent caspase pathways in rotenone-induced apoptosis in human neuroblastoma SH-SY5Y cells.

@article{Kitamura2002PossibleIO,
  title={Possible involvement of both mitochondria- and endoplasmic reticulum-dependent caspase pathways in rotenone-induced apoptosis in human neuroblastoma SH-SY5Y cells.},
  author={Yoshihisa Kitamura and Masatoshi Inden and Atsushi Miyamura and Jun-ichi Kakimura and Takashi Taniguchi and Shun Shimohama},
  journal={Neuroscience letters},
  year={2002},
  volume={333 1},
  pages={25-8}
}
Recently, it has been shown that rotenone, a specific inhibitor of mitochondrial complex I, is a useful tool in animal models of Parkinson's disease, but the mechanism of rotenone-induced neuronal death is not fully understood. In human neuroblastoma SH-SY5Y cells, rotenone induced the degradation of procaspases-12, -9 and -3, followed by cleavage of poly (adenosine diphosphate-ribose) polymerase, DNA fragmentation and cell death. Pretreatment with phorbol-12-myristate-13-acetate inhibited the… CONTINUE READING
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