Possible involvement of aminopeptidase A in hypertension and renal damage in Dahl salt-sensitive rats.

Abstract

BACKGROUND Although aminopeptidase A (APA), which is abundant in the kidneys, is responsible for metabolizing angiotensin II (Ang II), its association with salt sensitivity remains uncertain. We aimed to clarify the involvement of APA in salt-induced hypertension and renal damage. METHODS Male Dahl salt-sensitive (DS) and Dahl salt-resistant (DR) rats… (More)

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