Possible involvement of a novel STAM-associated molecule "AMSH" in intracellular signal transduction mediated by cytokines.

@article{Tanaka1999PossibleIO,
  title={Possible involvement of a novel STAM-associated molecule "AMSH" in intracellular signal transduction mediated by cytokines.},
  author={Nobuyuki Tanaka and Keiko Kaneko and Hironobu Asao and Hirotake Kasai and Yoko Endo and Takashi Fujita and Toshikazu Takeshita and Kazuo Sugamura},
  journal={The Journal of biological chemistry},
  year={1999},
  volume={274 27},
  pages={19129-35}
}
STAM containing an SH3 (Src homology 3) domain and an immunoreceptor tyrosine-based activation motif was previously revealed to be implicated in signaling pathways immediately downstream of Jak2 and Jak3 tyrosine kinases associated with cytokine receptors. We molecularly cloned a novel molecule interacting with the SH3 domain of STAM, which was named AMSH (associated molecule with the SH3 domain of STAM). AMSH contains a putative bipartite nuclear localization signal and a homologous region of… CONTINUE READING

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