Possible involvement of PPARγ-associated eNOS signaling activation in rosuvastatin-mediated prevention of nicotine-induced experimental vascular endothelial abnormalities

@article{Kathuria2012PossibleIO,
  title={Possible involvement of PPAR$\gamma$-associated eNOS signaling activation in rosuvastatin-mediated prevention of nicotine-induced experimental vascular endothelial abnormalities},
  author={Sonam Kathuria and Nanjaian Mahadevan and Pitchai Balakumar},
  journal={Molecular and Cellular Biochemistry},
  year={2012},
  volume={374},
  pages={61-72}
}
Nicotine exposure via cigarette smoking and tobacco chewing is associated with vascular complications. The present study investigated the effect of rosuvastatin in nicotine (2 mg/kg/day, i.p., 4 weeks)-induced vascular endothelial dysfunction (VED) in rats. The development of VED was assessed by employing isolated aortic ring preparation and estimating aortic and serum nitrite/nitrate concentration. Further, scanning electron microscopy and hematoxylin-eosin staining of thoracic aorta were… 
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TLDR
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TLDR
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TLDR
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