Possible involvement of P2Y2 metabotropic receptors in ATP-induced transient receptor potential vanilloid receptor 1-mediated thermal hypersensitivity.

@article{Moriyama2003PossibleIO,
  title={Possible involvement of P2Y2 metabotropic receptors in ATP-induced transient receptor potential vanilloid receptor 1-mediated thermal hypersensitivity.},
  author={Tomoko Moriyama and Takahiko Iida and Kimiko Kobayashi and Tomohiro Higashi and Toyokazu Fukuoka and Hideki Tsumura and Catherine L{\'e}on and Noboru Suzuki and Kazuhide Inoue and Christian Gachet and Koichi Noguchi and Makoto Tominaga},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2003},
  volume={23 14},
  pages={
          6058-62
        }
}
The capsaicin receptor transient receptor potential V1 (TRPV1; also known as vanilloid receptor 1) is a sensory neuron-specific ion channel that serves as a polymodal detector of pain-producing chemical and physical stimuli. It has been reported that extracellular ATP potentiates the TRPV1 currents evoked by capsaicin or protons and reduces the temperature threshold for its activation through metabotropic P2Y receptors in a PKC-dependent pathway, suggesting that TRPV1 activation could trigger… CONTINUE READING

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