Possible involvement of IkappaB kinase 2 and MKK7 in osteoclastogenesis induced by receptor activator of nuclear factor kappaB ligand.

@article{Yamamoto2002PossibleIO,
  title={Possible involvement of IkappaB kinase 2 and MKK7 in osteoclastogenesis induced by receptor activator of nuclear factor kappaB ligand.},
  author={Aiichiro Yamamoto and Tsuyoshi Miyazaki and Yuho Kadono and Hiroshi Takayanagi and Toshiki Miura and Hiroshi Nishina and Toshiaki Katada and Kenji Wakabayashi and Hiromi Oda and Kozo Nakamura and Sakae Tanaka},
  journal={Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research},
  year={2002},
  volume={17 4},
  pages={612-21}
}
Recent studies have revealed the essential role of the receptor activator of nuclear factor kappaB (NF-kappaB) ligand (RANKL) in osteoclast differentiation and activation. Adenovirus vector could efficiently transduce genes into RAW264.7 cells, which differentiate into osteoclast-like multinucleated cells in the presence of RANKL. The role of NF-kappaB and c-jun N-terminal kinase (JNK) activation in RANKL-induced osteoclast differentiation was investigated using an adenovirus vector carrying… CONTINUE READING

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