Possible involvement and the mechanisms of excess trans-fatty acid consumption in severe NAFLD in mice.

@article{Obara2010PossibleIA,
  title={Possible involvement and the mechanisms of excess trans-fatty acid consumption in severe NAFLD in mice.},
  author={Noriyuki Obara and Koji Fukushima and Yoshiyuki Ueno and Yuta Wakui and Osamu de Sandes Kimura and Keiichi Tamai and Eiji Kakazu and Jun Inoue and Yasuteru Kondo and Norihiko Ogawa and Kenta Sato and Tsuyoshi Tsuduki and Kazuyuki Ishida and Tooru Shimosegawa},
  journal={Journal of hepatology},
  year={2010},
  volume={53 2},
  pages={326-34}
}
BACKGROUND & AIMS Excessive trans-fatty acids (TFA) consumption has been thought to be a risk factor mainly for coronary artery diseases while less attention has been paid to liver disease. We aimed to clarify the impact of TFA-rich oil consumption on the hepatic pathophysiology compared to natural oil. METHODS Mice were fed either a low-fat (LF) or high-fat (HF) diet made of either natural oil as control (LF-C or HF-C) or partially hydrogenated oil, TFA-rich oil (LF-T or HF-T) for 24 weeks… CONTINUE READING